Bad pubmed problem?

Just tried this DA Pro search [a scheduled search I’ve run a few times now], in which the crucial part is to return items having “sex ratio” as part of the result. Search => “sex ratio” AND (rat OR rats OR [etc] OR human* OR mammalian) AND (toxic* [etc]) NOT (mite OR wasp [etc])

The problem is that some of my high ranking results do not actually have “sex ratio” in the result at all. However >> they appear to have “sex ratio” in the “Recent Activity” part of the page – i.e., other recent pubmed searches. I assume this is happening in real time, and so the DA engine is truly being confused by its own previous search results against Pubmed (or maybe one of mine?), in which it did find a result with “sex ratio”.

I’ve attached the page so you can see what I mean.

Pubmed is a vital resource to my work, and finding the results through pubmed (rather than, say, Google Scholar) is much better for a number of reasons (e.g., getting the PDFs through the university).

Any thoughts on how to stop this problem? Thanks much.

Could you please switch to the text view (see Web > View > Text) and check whether the text contains the desired terms? In addition, the next maintenance release will update the PubMed plugin. If you’re interested in a beta, just send me an email.

Hi Christian,

I haven’t looked at very many, but here’s an example in text view [below].

Incidentally, I looked at my search again and see that it has less () than I thought. But i don’t think that would cause this problem. The search was: “sex ratio” AND [various animals] AND [various chemicals] NOT [various insects]

I don’t actually know how the precedence of the logical operators would work here.

Thanks.

[b]~~~~~~~~ EXAMPLE: “sex ratio” is not found in this hit. It is found in the massive amount of other stuff laying around the pubmed page – in this case, “recent activity [aka searches]”[/b]

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Toxicol Lett. 2011 Dec 15;207(3):298-305. Epub 2011 Sep 29.

Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys.

Doerge DR , Twaddle NC , Vanlandingham M , Fisher JW .

Source

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. daniel.doerge@fda.hhs.gov

Abstract

Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure at levels largely below 1 μg/kg bw/d. The current study used LC/MS/MS to measure serum pharmacokinetics of unconjugated (active) and conjugated (inactive) BPA in adult and neonatal CD-1 mice by oral and subcutaneous (SC) injection routes. Deuterated BPA was used to avoid issues of background contamination. Significant inverse relationships were observed between postnatal age and measures of internal exposures (C(max)) to unconjugated BPA after oral administration. Phase II conjugation, area under the time-concentration curve (AUC), and elimination half-time of unconjugated BPA were also inversely related to age. In postnatal day (PND) 3 mice, the combination of under-developed Phase II metabolism, rapid absorption, and slow elimination kinetics led to equivalent internal exposures for unconjugated BPA from oral and SC routes; however, maturing metabolic capabilities in PND 10 and older mice, led to large and significant route effects. The significant inverse age-related developmental profiles from PND 3 through adulthood for unconjugated BPA internal exposure metrics from oral administration to CD-1 mice and Sprague-Dawley rats were remarkably similar; however, the developmental profile was quite different for neonatal rhesus monkeys in which small insignificant age-related differences were observed. These results suggest that an adverse effect from BPA observed in rodent models, attributable to exposure during a discrete time period of neonatal development, would be less likely for comparable neonatal primate dosing based on internal dosimetry. On the other hand in all adults of all species studied, including humans, a low oral dose of BPA produced similarly small internal exposures for the unconjugated form, reflecting the dominant effect of presystemic Phase II metabolism.

Published by Elsevier Ireland Ltd.

PMID:
21983029
[PubMed - indexed for MEDLINE]
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Research Support, N.I.H., Extramural
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MeSH Terms

Administration, Oral
Age Factors
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Animals, Newborn/metabolism
Female
Injections, Subcutaneous
Macaca mulatta
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Mice
Phenols/administration & dosage
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bisphenol A
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Could you please save the search (via File > Save As…) as an .agentSearch file, zip the file and send it to cgrunenberg - at - devon-technologies.com? Thanks in advance!

Greetings,

I’m trying to develop several specific searches for pubMed using DA, but am running into difficulty with the specifics. For example I would like to do a reoccurring search for a specific author(i.e., Friston, etc.). Would anyone mind sharing their knowledge on where I can find this information or how to setup this type of query? I think I can get the reoccurring portion figured out…

Also, does anyone know why DTP pub med search returns completely different results from DA?

Thanks to any/all. Any help is greatly appreciated.

Cheers,
Jason