Initial Copy of Large (~Gig) Databases to New iPad via wire?

Can I copy my gig-sized DT databases to the new iPad using USB synch (iTunes), or must I use the WiFi synch? I am concerned about such large files holding up during the Wi-Fi synch.

I ask because I am tempted to upgrade my original iPad for the latest version 3 with the more robust internal memory and zippier processor. And have had the large file transfers fail in my attempts on my iPad 1.

If I could have all my DT dbs on my iPad, then I could have all my information truly accessible to me always! Nerd nirvana!