In my experience the combination of Hazel and DEVONthink allows you to develop really sophisticated workflows for manipulating files. I would not wish to be without either app.
In passing, and expressing a purely personal opinion, CleanMyMac does not fall into that category of app. I’m exceptionally wary of apps that purport to "clean” things. Where appropriate I rely on Hazel, again, to delete unwanted linked files when deleting an app (after rather careful consideration of the list of files that will also be deleted).
Stephen