What aspect of a database slows it the most?

[korm]

Perhaps this is helpful:

Ideal number of databases to keep

Dear friends, I am using DEVONthink Pro office for all my personal and professional file management and note taking needs. Up until now I have been keeping a number of databases - e.g. reviews, manuscripts, publications, presentations, curriculum vitae and biosketches, conferences and workshops, notes, etc - However, this has proven not as practical in that at times I run into instances when it is not clear where it would be best to safe a document. I am thinking of restructuring my documents …