Working on a file within DTPO

I want to store my PDF’s in DTPO but I need to edit and annotate PDF’s from Skim. to

Is there an easy way of doing this that does not involve constant saving and copying or is this a clear case of using indexing rather than importing/deleting as my approach?

Which I suppose would mean ending up with all PDF’s which are likely to be edited stored in Finder and the rest in DTOP…

thanks

You can edit your files in any application via Data > Open With.

Or if you’re a keyboard shortcut nut like me: CMD-Shift-O