Yes I mean in fewer than 3 clicks (actually, it’s 4), and not in a preferences panel where one can make unintended changes. One shouldn’t have to pop the hood of a car to check how many miles it has been driven.
Also, to put the question in context, I have limited vision, often use screen magnification, and constantly clicking through menus is not ideal. My experience has been that Devonthink’s sync functionality is not 100% reliable (and yes, I’m using one of the supported options). More than once I have changed locations and found that sync had not taken place. Therefore, every time I change locations, I need to check the sync status. Going into the preferences pane every time, and being super careful not to change anything unintentionally, is simple not efficient.