Sorry about the lack of specifics in my post and the cryptic doesn’t play well statement. I should have waited until today when I have more time.
I used Migration Assistant to copy my files and settings from a mid-2018 MacBook Pro to my new 16" MacBook Pro M1 Max. I usually do a clean install when setting up a new machine, but my installation was running so well I decided to do it the easy way.
I noticed early on that the DEVONthink Mail Plug-in was not working, so I activated it by adding the necessary checkmark in Mail Preferences. NOTE: the computer was running macOS 12.0 at this point and the version of DEVONthink_BigSur.mailbundle was not the latest. The plug-in functioned as expected at this point.
I upgraded to macOS 12.0.1, after which I received a message stating Incompatible Plug-ins Disabled. I opened preferences, rechecked the Plug-in only to receive the message again.
I then searched my drive for and found a newer version of DEVONthink_BigSur.mailbundle dated October 7, 2021 at 6:38 AM. I copied this to the former location of the older version. I then checked the new Plug-in in Mail Preferences, Mail closed and reopened with the same warning.
To respond to your questions:
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Yes, Rosetta is installed. I had no other choice if I wanted to run some necessary apps.
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I didn’t think of checking Install Add-Ons at the time, but Apple Mail Plugin is unchecked and grayed out.
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I tried deleting and reinstalling. Clicking on Install Add-Ons brings me to the Handbooks and Extras web page that lists no Apple Mail Plugins.
I could be wrong, but It appears to me that macOS 12.0.1 broke the Mail Plug-in’s functionality.