Here is the Instrument.app log for Devonthink recorded during 2 severe hangs (~10 s each).
Weight Self Weight Symbol Name
3.85 s 100.0% 0 s DEVONthink 3 (58103)
2.81 s 73.0% 0 s start
2.81 s 73.0% 0 s 0x100511514
2.81 s 73.0% 0 s NSApplicationMain
2.81 s 73.0% 0 s -[NSApplication run]
2.80 s 72.8% 0 s -[DevonApplication _nextEventMatchingEventMask:untilDate:inMode:dequeue:]
2.80 s 72.8% 0 s -[NSApplication(NSEventRouting) _nextEventMatchingEventMask:untilDate:inMode:dequeue:]
2.80 s 72.7% 0 s _DPSNextEvent
2.80 s 72.7% 0 s _BlockUntilNextEventMatchingListInModeWithFilter
2.80 s 72.7% 0 s ReceiveNextEventCommon
2.80 s 72.7% 0 s RunCurrentEventLoopInMode
2.80 s 72.7% 0 s CFRunLoopRunSpecific
2.80 s 72.7% 0 s __CFRunLoopRun
2.75 s 71.5% 0 s __CFRunLoopDoTimers
2.75 s 71.5% 0 s __CFRunLoopDoTimer
2.75 s 71.5% 0 s __CFRUNLOOP_IS_CALLING_OUT_TO_A_TIMER_CALLBACK_FUNCTION__
2.75 s 71.3% 0 s __NSFireDelayedPerform
2.74 s 71.1% 0 s 0x100651de0
2.73 s 71.0% 0 s 0x100651b98
2.73 s 71.0% 0 s 0x1006623b0
2.73 s 70.9% 1.00 ms 0x100660748
2.29 s 59.3% 1.00 ms 0x10060ab04
1.95 s 50.7% 5.00 ms 0x1005bddb0
1.81 s 47.1% 0 s -[NSFileCoordinator coordinateReadingItemAtURL:options:error:byAccessor:]
1.81 s 47.0% 1.00 ms -[NSFileCoordinator(NSPrivate) _coordinateReadingItemAtURL:options:error:byAccessor:]
1.63 s 42.4% 3.00 ms -[NSFileCoordinator(NSPrivate) _withAccessArbiter:invokeAccessor:orDont:andRelinquishAccessClaim:]
1.47 s 38.1% 0 s __85-[NSFileCoordinator(NSPrivate) _coordinateReadingItemAtURL:options:error:byAccessor:]_block_invoke.207
1.47 s 38.1% 0 s __73-[NSFileCoordinator coordinateReadingItemAtURL:options:error:byAccessor:]_block_invoke
1.47 s 38.1% 0 s -[NSFileCoordinator _invokeAccessor:thenCompletionHandler:]
1.17 s 30.2% 1.00 ms 0x10066114c
472.00 ms 12.2% 3.00 ms +[DTMetaDataStore(Tagging) getFinderTags:error:]
459.00 ms 11.9% 1.00 ms -[NSFileManager(DevonFileManagerExtensions) getResourceValueForKey:atPath:error:]
440.00 ms 11.4% 0 s -[NSURL getResourceValue:forKey:error:]
438.00 ms 11.3% 2.00 ms CFURLCopyResourcePropertyForKey
435.00 ms 11.3% 0 s _FSURLCopyResourcePropertyForKeyInternal(__CFURL const*, __CFString const*, void*, void*, __CFError**, unsigned char)
428.00 ms 11.1% 0 s prepareValuesForBitmap(__CFURL const*, __FileCache*, _FilePropertyBitmap*, __CFError**)
332.00 ms 8.6% 0 s ExternalProviderPrepareValues(__CFURL const*, __FileCache*, __CFString const* const*, void const**, long, void const*, __CFError**)
325.00 ms 8.4% 2.00 ms _DS_CFURLGetPropertyForKey
323.00 ms 8.3% 0 s DS_CFURLGetTagProperty(__CFURL const*, void const**, __CFError**)
321.00 ms 8.3% 0 s NodeCopyTagsAndAttributes
288.00 ms 7.4% 0 s TFSInfo::CopyTagsAndAttributes(bool) const
284.00 ms 7.3% 0 s TFSInfo::CopyTagsForPath() const
282.00 ms 7.3% 1.00 ms _MDItemCopyExAttrWithURL
277.00 ms 7.2% 1.00 ms _MDCopyExtendedAttributeInternal
273.00 ms 7.0% 0 s copyExtendedAttribute
265.00 ms 6.8% 265.00 ms getxattr
7.00 ms 0.1% 0 s CFPropertyListCreateWithData
1.00 ms 0.0% 1.00 ms __CFDataInit
2.00 ms 0.0% 2.00 ms CFStringGetCString
1.00 ms 0.0% 1.00 ms _platform_memset
1.00 ms 0.0% 1.00 ms _MDCopyExtendedAttributeForPath
1.00 ms 0.0% 1.00 ms CanonicalFileURLStringToFileSystemRepresentation
1.00 ms 0.0% 0 s CFURLGetFileSystemRepresentation
1.00 ms 0.0% 1.00 ms DYLD-STUB$$bzero
1.00 ms 0.0% 0 s TRef<__CFURL const*, TRetainReleasePolicy<__CFURL const*>>::~TRef()
1.00 ms 0.0% 1.00 ms TAutoRef<void const*, TRetainReleasePolicy<void const*>>::~TAutoRef()
3.00 ms 0.0% 0 s TCFURLInfo::DecodeEncodedTagString(void const*)
1.00 ms 0.0% 1.00 ms -[__NSPlaceholderArray initWithCapacity:]
13.00 ms 0.3% 0 s TFSInfo::initialize(__CFURL const*, LSProperties, bool, bool, bool)
10.00 ms 0.2% 0 s TFSInfo::GetLabel() const
5.00 ms 0.1% 1.00 ms std::__1::__shared_weak_count::__release_shared[abi:v160006]()
3.00 ms 0.0% 0 s std::__1::shared_ptr<TFSInfo> std::__1::allocate_shared[abi:v160006]<TFSInfo, std::__1::allocator<TFSInfo>, void>(std::__1::allocator<TFSInfo> const&)
1.00 ms 0.0% 1.00 ms operator delete(void*)
1.00 ms 0.0% 1.00 ms std::__1::__shared_weak_count::__release_weak()
1.00 ms 0.0% 1.00 ms -[__NSArrayM objectAtIndex:]
1.00 ms 0.0% 1.00 ms CFArrayGetCount
7.00 ms 0.1% 0 s _FileCacheSetPropertyValueForKey
94.00 ms 2.4% 0 s corePropertyProviderPrepareValues(__CFURL const*, __FileCache*, __CFString const* const*, void const**, long, void const*, __CFError**)
1.00 ms 0.0% 1.00 ms _FileCacheDecrementInProvider(__FileCache*)
1.00 ms 0.0% 1.00 ms GetFromDesktopServices(__CFURL const*, void const*, void const**, __CFError**)
4.00 ms 0.1% 3.00 ms ExternalProviderCopyValues(__CFURL const*, __FileCache const*, __CFString const* const*, void const**, void const**, long, void const*)
2.00 ms 0.0% 0 s _FileCacheGetForURL(__CFURL const*, void*)
1.00 ms 0.0% 1.00 ms _FileCacheLockTransitionToPreparer(__FileCache const*)
1.00 ms 0.0% 1.00 ms prepareValuesForBitmap(__CFURL const*, __FileCache*, _FilePropertyBitmap*, __CFError**)
2.00 ms 0.0% 1.00 ms -[NSURL(NSURL) _cfurl]
11.00 ms 0.2% 1.00 ms _CFURLCreateWithFileSystemPath
5.00 ms 0.1% 0 s _CFRelease
1.00 ms 0.0% 0 s -[NSURL(NSURL) initFileURLWithPath:isDirectory:]
1.00 ms 0.0% 1.00 ms -[NSURL(NSURL) release]
8.00 ms 0.2% 1.00 ms -[NSUserDefaults(NSUserDefaults) boolForKey:]
2.00 ms 0.0% 2.00 ms +[NSFileManager defaultManager]
204.00 ms 5.3% 1.00 ms 0x100602340
148.00 ms 3.8% 0 s +[DTMetaDataStore objectForKey:atPath:traverseLink:error:]
129.00 ms 3.3% 0 s -[NSURL getResourceValue:forKey:error:]
129.00 ms 3.3% 0 s CFURLCopyResourcePropertyForKey
128.00 ms 3.3% 1.00 ms _FSURLCopyResourcePropertyForKeyInternal(__CFURL const*, __CFString const*, void*, void*, __CFError**, unsigned char)
116.00 ms 3.0% 1.00 ms prepareValuesForBitmap(__CFURL const*, __FileCache*, _FilePropertyBitmap*, __CFError**)
113.00 ms 2.9% 0 s corePropertyProviderPrepareValues(__CFURL const*, __FileCache*, __CFString const* const*, void const**, long, void const*, __CFError**)
2.00 ms 0.0% 2.00 ms PropertyMaskIsNotZero(_FilePropertyMask const*, long*, long*)
4.00 ms 0.1% 0 s corePropertyProviderCopyAndCacheValues(__CFURL const*, __FileCache*, __CFString const* const*, void const**, void const**, long, void const*)
3.00 ms 0.0% 1.00 ms corePropertyProviderCopyValues(__CFURL const*, __FileCache const*, __CFString const* const*, void const**, void const**, long, void const*)
2.00 ms 0.0% 0 s _FileCacheLock(__FileCache const*)
1.00 ms 0.0% 0 s getPropertyForKey(__CFString const*)
1.00 ms 0.0% 1.00 ms addPropertyAndDependenciesToBitmap(_FileProperty const*, _FilePropertyBitmap*)
1.00 ms 0.0% 0 s _CFURLHasFileURLScheme
78.00 ms 2.0% 0 s 0x100660114
36.00 ms 0.9% 1.00 ms 0x1006013a0
33.00 ms 0.8% 1.00 ms -[NSUserDefaults(NSUserDefaults) boolForKey:]
16.00 ms 0.4% 0 s -[NSArray(NSArrayDevonExtensions) containsObjectIdenticalTo:]
14.00 ms 0.3% 0 s +[DSStore finderCommentModificationDateAtPath:]
7.00 ms 0.1% 0 s -[NSURL(NSURL) path]
4.00 ms 0.1% 0 s -[NSString(NSStringDevonCloudExtensions) isGoogleDriveFolder]
4.00 ms 0.1% 1.00 ms 0x1005fd9e8
3.00 ms 0.0% 0 s -[NSString(NSStringDevonCloudExtensions) isOneDriveFolder]
3.00 ms 0.0% 3.00 ms objc_msgSend
2.00 ms 0.0% 0 s validatedTags
2.00 ms 0.0% 1.00 ms 0x1005fd27c
2.00 ms 0.0% 0 s 0x100661598
2.00 ms 0.0% 0 s 0x1005fd30c
1.00 ms 0.0% 1.00 ms 0x10060c94c
1.00 ms 0.0% 0 s 0x1005fd380
1.00 ms 0.0% 1.00 ms -[NSObject isMemberOfClass:]
1.00 ms 0.0% 1.00 ms 0x10075a561
1.00 ms 0.0% 1.00 ms 0x10078e38d
234.00 ms 6.0% 0 s 0x1006617c4
55.00 ms 1.4% 0 s -[NSFileCoordinatorAccessorBlockCompletion decrement]
6.00 ms 0.1% 1.00 ms +[NSFileCoordinatorAccessorBlockCompletion completionWithBlock:]
2.00 ms 0.0% 0 s 0x1005bdf30
2.00 ms 0.0% 2.00 ms 0x100777da1
1.00 ms 0.0% 0 s NSFileCoordinatorGetTSD
1.00 ms 0.0% 1.00 ms 0x100789221
138.00 ms 3.5% 0 s -[NSFileAccessClaim _protectIfNecessaryFileAtURL:withOptions:forReading:]
21.00 ms 0.5% 1.00 ms _NSSetThreadSpecificMaterializationState
2.00 ms 0.0% 2.00 ms objc_msgSend
2.00 ms 0.0% 0 s -[NSFileAccessClaim claimID]
1.00 ms 0.0% 1.00 ms _objc_rootAutorelease
1.00 ms 0.0% 1.00 ms objc_msgSend$_protectIfNecessaryFileAtURL:withOptions:forReading:
93.00 ms 2.4% 1.00 ms -[NSFileCoordinator(NSPrivate) _blockOnAccessClaim:withAccessArbiter:]
53.00 ms 1.3% 0 s -[NSFileReadingClaim initWithPurposeID:url:options:claimer:]
9.00 ms 0.2% 0 s _os_log_impl
8.00 ms 0.2% 0 s -[NSFileReadingClaim dealloc]
4.00 ms 0.1% 2.00 ms +[NSArray arrayWithObjects:]
3.00 ms 0.0% 1.00 ms consumeSandboxTokens
2.00 ms 0.0% 1.00 ms -[NSFileAccessClaim claimID]
1.00 ms 0.0% 1.00 ms objc_retain
1.00 ms 0.0% 1.00 ms objc_retain_x28
1.00 ms 0.0% 1.00 ms DYLD-STUB$$free
1.00 ms 0.0% 1.00 ms _nanov2_free
1.00 ms 0.0% 1.00 ms objc_msgSend
75.00 ms 1.9% 0 s -[NSString(NSStringDevonPathExtensions) isRemoteVolumePath]
34.00 ms 0.8% 3.00 ms 0x1005bd800
13.00 ms 0.3% 0 s 0x1005bd904
6.00 ms 0.1% 2.00 ms -[NSString(NSStringDevonCloudExtensions) isVolatileFolder]
4.00 ms 0.1% 0 s +[NSDate timeIntervalSinceReferenceDate]
2.00 ms 0.0% 0 s -[NSURL(NSURL) path]
1.00 ms 0.0% 1.00 ms objc_msgSend
1.00 ms 0.0% 1.00 ms _CFRelease
278.00 ms 7.2% 0 s 0x100609e8c
29.00 ms 0.7% 0 s objc_autoreleasePoolPop
8.00 ms 0.2% 0 s _CFURLCreateWithFileSystemPath
7.00 ms 0.1% 1.00 ms _CFRelease
4.00 ms 0.1% 3.00 ms 0x1005fd920
1.00 ms 0.0% 1.00 ms 0x10055d234
1.00 ms 0.0% 1.00 ms 0x10061b350
1.00 ms 0.0% 1.00 ms 0x100769241
1.00 ms 0.0% 1.00 ms AutoreleasePoolPage::push()
1.00 ms 0.0% 1.00 ms -[NSURL(NSURLDevonExtensions) initFileURLWithAbsolutePath:]
421.00 ms 10.9% 0 s 0x10060a3a0
10.00 ms 0.2% 0 s objc_autoreleasePoolPop
6.00 ms 0.1% 2.00 ms 0x1005f256c
2.00 ms 0.0% 0 s 0x1005dce70
1.00 ms 0.0% 1.00 ms objc_msgSend
1.00 ms 0.0% 1.00 ms 0x100763e81
1.00 ms 0.0% 1.00 ms 0x1005f25d0
1.00 ms 0.0% 1.00 ms 0x100764801
1.00 ms 0.0% 1.00 ms 0x100764421
1.00 ms 0.0% 1.00 ms 0x1005f2738
3.00 ms 0.0% 0 s 0x10060ab04
3.00 ms 0.0% 0 s 0x1005bddb0
3.00 ms 0.0% 0 s -[NSFileCoordinator coordinateReadingItemAtURL:options:error:byAccessor:]
3.00 ms 0.0% 0 s -[NSFileCoordinator(NSPrivate) _coordinateReadingItemAtURL:options:error:byAccessor:]
3.00 ms 0.0% 0 s -[NSFileCoordinator(NSPrivate) _withAccessArbiter:invokeAccessor:orDont:andRelinquishAccessClaim:]
3.00 ms 0.0% 0 s __85-[NSFileCoordinator(NSPrivate) _coordinateReadingItemAtURL:options:error:byAccessor:]_block_invoke.207
3.00 ms 0.0% 0 s __73-[NSFileCoordinator coordinateReadingItemAtURL:options:error:byAccessor:]_block_invoke
3.00 ms 0.0% 0 s -[NSFileCoordinator _invokeAccessor:thenCompletionHandler:]
3.00 ms 0.0% 0 s 0x1006624e4
1.00 ms 0.0% 1.00 ms 0x1007537c1
2.00 ms 0.0% 0 s 0x1006dd7a4
7.00 ms 0.1% 0 s 0x1005d5474
1.00 ms 0.0% 0 s -[NSDictionary(NSDictionary) writeToFile:atomically:]
3.00 ms 0.0% 0 s _CFAutoreleasePoolPop
3.00 ms 0.0% 0 s ___NSRunLoopTimerCreateWithHandler_block_invoke
1.00 ms 0.0% 0 s -[NSApplication(NSQuietSafeQuit) _updateCanQuitQuietlyAndSafely]
1.00 ms 0.0% 0 s __NSFireTimer
46.00 ms 1.1% 0 s __CFRunLoopDoObservers
1.00 ms 0.0% 1.00 ms __kdebug_trace64
1.00 ms 0.0% 0 s _NSSendEventToDequeuingObservers
8.00 ms 0.2% 0 s -[NSApplication _handleEvent:]
1.02 s 26.5% 0 s start_wqthread
833.00 ms 21.6% 0 s _pthread_wqthread
187.00 ms 4.8% 187.00 ms start_wqthread
18.00 ms 0.4% 0 s thread_start
18.00 ms 0.4% 0 s _pthread_start
18.00 ms 0.4% 0 s _NSEventThread
I could provide the longer more detailed if requested (can’t put link here).