How do we delete Version 2 after upgrade to V3?

You definitely don’t “need to keep the DEVONthink Pro 2 folder to run DEVONthink 3”.

As @kfast mentioned, if you have some custom resources (templates, scripts, etc.) you’ve added, you’d need to migrate those manually. Otherwise, here is the current list for a full uninstall…

To do a deeper clean when moving from DEVONthink Pro (Office) 2 to DEVONthink 3…
Note: While it is not a prerequisite, we strongly recommend making sure your proper primary backups are current before starting this process.

Trash the following files and folders, noting the tilde (~) signifies the User Library:

  • DEVONthink Pro (Office) application
  • ~/Library/Application Support/DEVONthink Pro 2
  • ~/Library/Preferences/com.devon-technologies.thinkpro2.*
  • All DEVONthink Pro Office-specific scripts in ~/ Library/Scripts/
  • All DEVONthink Pro Office-specific workflows in ~/Library/Workflows/
  • All DEVONthink Pro Office-specific scripts in ~/ Library/PDF Services/
  • DEVONthink related Bookmarklets from your web browser
  • The Inbox in the sidebar of your Finder windows
  • Delete the DEVONthink Sorter from System Preferences > Users & Groups > Login Items , if present.

Then reboot the machine.